It would not be an understatement to say that Danny Trejo is one of the quintessential indie film actors of our generation. His early upbringing would suggest that his future would find him in a prison cell, not on a movie set. Born in the Echo Park region of Los Angeles, as a youth, Trejo roamed the streets around his home area, committing various crimes and became addicted to drugs. He was in and out of jail many times as a teenager. It was while he was enrolled in a twelve-step program that he found acting.

Since then, Trejo has become a prolific actor in both films and television, acting alongside some of Hollywood's most famous actors, including Johnny Depp, Al Pacino, Nicolas Cage, Charles Bronson, George Clooney, John Malkovich, Robert De Niro, Harrison Ford, Val Kilmer, and Antonio Banderas. Trejo has often appeared in five or more movies per year in various genres. Major releases in which he has acted include: Blood in Blood Out, Animal Factory, Anaconda, xXx, Desperado, Once Upon a Time in Mexico, Heat, From Dusk Till Dawn, Con Air, Six Days Seven Nights, Spy Kids, The Replacement Killers, Anchorman: The Legend of Ron Burgundy, The Devil's Rejects, Valley of Angels, Delta Farce, Grindhouse, Rob Zombie's Halloween and Snoop Dogg's Hood of Horror.

The independent film Champion was released in 2005, documenting Trejo's life and featuring appearances by friends and associates from the film industry. His cousin is filmmaker, Robert Rodriguez.